💊 Pain Killers Today, Gut Trouble Tomorrow?
- Mark Wignarajah
- Apr 17
- 2 min read
When pain strikes, many of us reach for over-the-counter solutions like Ibuprofen or Naproxen — common non-steroidal anti-inflammatory drugs (NSAIDs). They're convenient, widely accessible, and undeniably effective at reducing inflammation and discomfort.
But there's a side to NSAIDs that doesn’t always get the spotlight — especially when it comes to your gut health.
The Gut-NSAID Connection
NSAIDs work by blocking enzymes called COX-1 and COX-2, which are responsible for inflammation and pain. However, COX-1 also plays a protective role in maintaining the stomach lining and supporting intestinal integrity. When we suppress this enzyme regularly, the gut can start to suffer.
🌪️ How NSAIDs Can Contribute to Gut Damage:
Increased Intestinal Permeability
Frequent NSAID use has been linked to "leaky gut" syndrome — a condition where the lining of the intestines becomes more permeable, allowing toxins and partially digested food to enter the bloodstream.
Inflammation and Ulceration
🫃🏻NSAIDs can lead to inflammation and even ulceration of the gastrointestinal tract. While stomach ulcers are well-known, damage can also occur in the small intestine — and it’s often silent until more serious symptoms arise.
🦠Gut Microbiome Imbalance
Emerging research shows NSAIDs may disrupt the delicate balance of gut bacteria, which are crucial for digestion, immunity, and even mental health.
💭So What Can You Do?
Use NSAIDs Sparingly: Reserve them for short-term use and only when truly needed.
🍲Support with Food: Always take NSAIDs with food to reduce their direct contact with the stomach lining.
🌿Explore Alternatives: Natural anti-inflammatories like turmeric, omega-3s, and physical therapies may offer relief with less risk.
👋Speak to Your GP or Pharmacist: Especially if you’re using NSAIDs regularly. Long-term strategies should be guided by a health professional.
Final Thoughts
Pain relief is important — but so is protecting the systems that keep us healthy long-term. Understanding the trade-offs of frequent NSAID use can empower you (or your team) to make better, more informed choices.
👉 Have you had experience with long-term NSAID use or gut issues? I’d love to hear your story or thoughts in the comments.
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